Hey everyone! I'm going to copy and paste from a similar thread in which a fellow user named Tory gave me a somewhat working solution. It's not perfect and I've had to reboot it on numerous occasions, but I've found it's the ONLY way to make it work.
M-AUDIO PLEASE GET A MOVE ON THE NEW DRIVERS. SERIOUSLY. IT IS OUTRAGEOUS THAT I HAVE TO GO THROUGH SO MUCH KJASDKLASJDASKLDJ TO GET MY PROFIRE TO WORK!
Anyway, I hope this helps.
Here it is:
Ok, this is solved. Thanks to all who have posted. I have asked everyone form M-Audio, Protools helpdesk, experts at Guitar Center, all to no avail. All have had good ideas but I now know what is going on. So that I may be able to help someone else, please follow what I did, I made sure that I could delineate this for not only myself but someone else. I hope this helps you Apostle Paw.
Using the latest OS (Mountain Lion 10.8.2) and connecting my Profire 2626 via 400 to 800 firewire. I am using both MIDI and the 8 analog inputs. First, there is no tested driver for 10.8.2 but the latest version will be tested at some point soon and it will probably not change. It has be ProfireSeries_OSX_2_3_3.dmg for some time. This functions but not without some tweaking.
1. Install the latest driver first. It is not about ProTools but about getting the signal path to function. I recommend using something simple ike Garage Band to check the signal.
2. Once the driver is installed, connect your 2626. Make sure that you install this AFTER you install the driver. Remember NEVER hot swap (connect or disconnect the unit while it is powered on). M-Audio made that very clear.
3. Power you 2626 on and launch the M-Audio driver (will bring up the software mixer). For use with your DAW software, set inputs 1 - 8 to analog in. For router out, set the 1 - 8 to software returns.
It should be noted here that nomenclature for the DSP processor is a little confusing (actually a lot confusing to me.) For Inputs, first tab on mixer software, that is the physical inputs. The second router tab is for the output of the signal that was sent from inputs (i.e. mic or guitar input). However, this signal is routed from mic (input) to software and then routed back to 2626. It is output from software / pc back to router. So in my opinion this should be router input. However, I think it is meant pc output to router input. This confused the heck out of me.
4. Go to the MIDI setting (in utilities folder) and check for the profire 2626. You should have ADAT and S/PDIF. If you see 2626, it wont work. Even if you set it to such, it will default back to ADAT ro S/PDIF.
5. Now add a new connection on the the bottom left called aggregate. You can name it whatever you want but the important thing is that you ad Profire 2626 analog. Here is where you get your audio output.
6. Proceed to the Sound setting in the system directory and select this aggregate that you have created. This will be the routing through the OS.
7. If the unit is off, then you wont have this as an option, but when you power it on it will activate. Remember, you can power the unit on and off just DO NOT unplug it connected.
8. Now you can open your favorite DAW software (use Garage band first for simplicity) and you should be good to go.
It should be noted that when you power the unit on, it is not set to use software returns. Once it is on, launch the m-audio mixer. The light on the right of the unit will flash until you make good connection. As long as it is powered, you can completely shutdown the mixer. You are only setting the DSP on board to the setting in the hardware section. It keeps these once you shut down the M-Audion software interface. Now, open up GB or ProTools and you should have signal in and out as well. Not, sometimes you may have to reboot the OS. You will know if the light on the right if the unit blinks.
Very lengthly but I felt as I should put out what I discovered. I could not find it anywhere. (I have a graduated from UHK "University of Hard Knocks" with honors.. LOL)